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TitleGlutathione transferase Omega 1-1 (GSTO1-1) modulates Akt and MEK1/2 signaling in human neuroblastoma cell SH-SY5Y.
Journal, issue, pagesProteins, Vol. 87, Page 588-595, Year 2019
Publish dateNov 27, 2017 (structure data deposition date)
AuthorsSaisawang, C. / Wongsantichon, J. / Robinson, R.C. / Ketterman, A.J.
External linksProteins / PubMed:30874320
MethodsX-ray diffraction
Resolution1.33 - 1.8 Å
Structure data

PDB-5yvn:
Human Glutathione Transferase Omega1
Method: X-RAY DIFFRACTION / Resolution: 1.33 Å

PDB-5yvo:
Human Glutathione Transferase Omega1 covalently bound to ML175 inhibitor
Method: X-RAY DIFFRACTION / Resolution: 1.8 Å

Chemicals

ChemComp-GSH:
GLUTATHIONE

ChemComp-SO4:
SULFATE ION

ChemComp-ACT:
ACETATE ION

ChemComp-HOH:
WATER

ChemComp-MLX:
N-{3-[(2-chloro-acetyl)-(4-nitro-phenyl)-amino]-propyl}-2,2,2-trifluoro-acetamide

Source
  • homo sapiens (human)
KeywordsTRANSFERASE / Inhibitor / GST / allosteric

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