+Search query
-Structure paper
Title | Displacement of WDR5 from Chromatin by a WIN Site Inhibitor with Picomolar Affinity. |
---|---|
Journal, issue, pages | Cell Rep, Vol. 26, Page 2916-2928.e13, Year 2019 |
Publish date | Jul 1, 2018 (structure data deposition date) |
Authors | Aho, E.R. / Wang, J. / Gogliotti, R.D. / Howard, G.C. / Phan, J. / Acharya, P. / Macdonald, J.D. / Cheng, K. / Lorey, S.L. / Lu, B. ...Aho, E.R. / Wang, J. / Gogliotti, R.D. / Howard, G.C. / Phan, J. / Acharya, P. / Macdonald, J.D. / Cheng, K. / Lorey, S.L. / Lu, B. / Wenzel, S. / Foshage, A.M. / Alvarado, J. / Wang, F. / Shaw, J.G. / Zhao, B. / Weissmiller, A.M. / Thomas, L.R. / Vakoc, C.R. / Hall, M.D. / Hiebert, S.W. / Liu, Q. / Stauffer, S.R. / Fesik, S.W. / Tansey, W.P. |
External links | Cell Rep / PubMed:30865883 |
Methods | X-ray diffraction |
Resolution | 1.1 - 2.56 Å |
Structure data | PDB-6dy7: PDB-6dya: PDB-6e1y: PDB-6e1z: PDB-6e22: PDB-6e23: |
Chemicals | ChemComp-HH7: ChemComp-DMS: ChemComp-SO4: ChemComp-HOH: ChemComp-HHM: ChemComp-HLM: ChemComp-HLP: ChemComp-HLS: ChemComp-HLJ: ChemComp-EPE: |
Source |
|
Keywords | TRANSFERASE/TRANSFERASE inhibitor / WD40 repeat / epigenetic / WDR5-MLL / WIN site / TRANSFERASE-TRANSFERASE inhibitor complex / epigenetics / MLL binding / WIN site inhibitor / gene regulation/inhibitor / WDR5 / WIN-site / fragment screening / structure-based design / mixed-lineage leukemia / DNA BINDING PROTEIN / dna binding protein-inhibitor complex / GENE REGULATION / gene regulation-inhibitor complex |