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TitleDiscovery of NV-5138, the first selective Brain mTORC1 activator.
Journal, issue, pagesSci Rep, Vol. 9, Page 4107-4107, Year 2019
Publish dateNov 7, 2018 (structure data deposition date)
AuthorsSengupta, S. / Giaime, E. / Narayan, S. / Hahm, S. / Howell, J. / O'Neill, D. / Vlasuk, G.P. / Saiah, E.
External linksSci Rep / PubMed:30858438
MethodsX-ray diffraction
Resolution3.3 Å
Structure data

PDB-6n0m:
CRYSTAL STRUCTURE OF SESTRIN2 IN COMPLEX WITH NV-0005138
Method: X-RAY DIFFRACTION / Resolution: 3.3 Å

Chemicals

ChemComp-K94:
4-(difluoromethyl)-L-leucine

Source
  • homo sapiens (human)
KeywordsSIGNALING PROTEIN / MTOR / LEUCINE / AMINO-ACID / SENSING

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