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TitleZika virus NS5 forms supramolecular nuclear bodies that sequester importin alpha and modulate the host immune and pro-inflammatory response in neuronal cells.
Journal, issue, pagesACS Infect Dis, Year 2019
Publish dateJun 8, 2017 (structure data deposition date)
AuthorsNg, I.H.W. / Chan, K. / Tan, M.J.A. / Gwee, C.P. / Smith, K.M. / Jeffress, S.J. / Saw, W.G. / Swarbrick, C.M.D. / Watanabe, S. / Jans, D. ...Ng, I.H.W. / Chan, K. / Tan, M.J.A. / Gwee, C.P. / Smith, K.M. / Jeffress, S.J. / Saw, W.G. / Swarbrick, C.M.D. / Watanabe, S. / Jans, D. / Gruber, G. / Forwood, J.K. / Vasudevan, S.G.
External linksACS Infect Dis / PubMed:30848123
MethodsX-ray diffraction
Resolution2.2 Å
Structure data

PDB-5w41:
Zika MR766 NLS in complex with Importin alpha subunit-1
Method: X-RAY DIFFRACTION / Resolution: 2.2 Å

Chemicals

ChemComp-HOH:
WATER

Source
  • mus musculus (house mouse)
  • zika virus (strain mr 766)
Keywordsviral protein/protein binding / Zika / Nuclear Transport / Importin / Karyopherin / Virus / MR766 / viral protein-protein binding complex

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