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TitleBis-Heteroaryl Pyrazoles: Identification of Orally Bioavailable Inhibitors of Activin Receptor-Like Kinase-2 (R206H).
Journal, issue, pagesChem. Pharm. Bull., Vol. 67, Page 224-235, Year 2019
Publish dateJul 27, 2018 (structure data deposition date)
AuthorsSekimata, K. / Sato, T. / Sakai, N. / Watanabe, H. / Mishima-Tsumagari, C. / Taguri, T. / Matsumoto, T. / Fujii, Y. / Handa, N. / Honma, T. ...Sekimata, K. / Sato, T. / Sakai, N. / Watanabe, H. / Mishima-Tsumagari, C. / Taguri, T. / Matsumoto, T. / Fujii, Y. / Handa, N. / Honma, T. / Tanaka, A. / Shirouzu, M. / Yokoyama, S. / Miyazono, K. / Hashizume, Y. / Koyama, H.
External linksChem. Pharm. Bull. / PubMed:30828000
MethodsX-ray diffraction
Resolution2.01 Å
Structure data

PDB-6acr:
Crystal structure of human ALK2 kinase domain with R206H mutation in complex with RK-59638
Method: X-RAY DIFFRACTION / Resolution: 2.01 Å

Chemicals

ChemComp-9TO:
N-(4-methoxyphenyl)-4-[3-(pyridin-3-yl)-1H-pyrazol-4-yl]pyrimidin-2-amine

ChemComp-SO4:
SULFATE ION

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsSIGNALING PROTEIN / Inhibitor / Complex / Kinase

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