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Structure paper

TitleMutagenic Replication of the Major Oxidative Adenine Lesion 7,8-Dihydro-8-oxoadenine by Human DNA Polymerases.
Journal, issue, pagesJ. Am. Chem. Soc., Vol. 141, Page 4584-4596, Year 2019
Publish dateJul 14, 2018 (structure data deposition date)
AuthorsKoag, M.C. / Jung, H. / Lee, S.
External linksJ. Am. Chem. Soc. / PubMed:30817143
MethodsX-ray diffraction
Resolution1.96 - 2.26 Å
Structure data

PDB-6e3r:
Structure of human DNA polymerase beta complexed with 8OA as the template base in a 1-nucleotide gapped DNA
Method: X-RAY DIFFRACTION / Resolution: 2.26 Å

PDB-6e3v:
Structure of human DNA polymerase beta complexed with 8OA in the template base paired with incoming non-hydrolyzable TTP
Method: X-RAY DIFFRACTION / Resolution: 1.96 Å

PDB-6e3w:
Structure of human DNA polymerase beta complexed with 8OA in the template base paired with incoming non-hydrolyzable GTP
Method: X-RAY DIFFRACTION / Resolution: 2.02 Å

Chemicals

ChemComp-NA:
Unknown entry

ChemComp-HOH:
WATER

ChemComp-MG:
Unknown entry

ChemComp-1FZ:
5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]thymidine

ChemComp-XG4:
2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]guanosine

Source
  • homo sapiens (human)
KeywordsDNA BINDING PROTEIN/DNA / DNA polymerase / TRANSFERASE-DNA complex / DNA BINDING PROTEIN / DNA BINDING PROTEIN-DNA complex

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