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Title | A comparative study of the binding properties, dipeptidyl peptidase-4 (DPP-4) inhibitory activity and glucose-lowering efficacy of the DPP-4 inhibitors alogliptin, linagliptin, saxagliptin, sitagliptin and vildagliptin in mice. |
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Journal, issue, pages | Endocrinol Diabetes Metab, Vol. 1, Page e00002-e00002, Year 2018 |
Publish date | Sep 18, 2017 (structure data deposition date) |
Authors | Berger, J.P. / SinhaRoy, R. / Pocai, A. / Kelly, T.M. / Scapin, G. / Gao, Y.D. / Pryor, K.A.D. / Wu, J.K. / Eiermann, G.J. / Xu, S.S. ...Berger, J.P. / SinhaRoy, R. / Pocai, A. / Kelly, T.M. / Scapin, G. / Gao, Y.D. / Pryor, K.A.D. / Wu, J.K. / Eiermann, G.J. / Xu, S.S. / Zhang, X. / Tatosian, D.A. / Weber, A.E. / Thornberry, N.A. / Carr, R.D. |
External links | Endocrinol Diabetes Metab / PubMed:30815539 |
Methods | X-ray diffraction |
Resolution | 1.77 - 1.91 Å |
Structure data | PDB-6b1e: PDB-6b1o: |
Chemicals | ChemComp-LF7: ChemComp-NAG: ChemComp-NA: ChemComp-HOH: ChemComp-C8S: |
Source |
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Keywords | HYDROLASE/HYDROLASE Inhibitor / Diabetes / DPP4 inhibitors / covalent inhibitors / HYDROLASE / HYDROLASE-HYDROLASE Inhibitor complex |