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TitleStructural and Functional Characterization of Sulfonium Carbon-Oxygen Hydrogen Bonding in the Deoxyamino Sugar Methyltransferase TylM1.
Journal, issue, pagesBiochemistry, Vol. 58, Page 2152-2159, Year 2019
Publish dateAug 21, 2018 (structure data deposition date)
AuthorsFick, R.J. / Horowitz, S. / McDole, B.G. / Clay, M.C. / Mehl, R.A. / Al-Hashimi, H.M. / Scheiner, S. / Trievel, R.C.
External linksBiochemistry / PubMed:30810306
MethodsX-ray diffraction
Resolution1.3685 - 1.782 Å
Structure data

PDB-6m81:
Crystal structure of TylM1 Y14F bound to SAH and dTDP-phenol
Method: X-RAY DIFFRACTION / Resolution: 1.782 Å

PDB-6m82:
Crystal structure of TylM1 Y14paF bound to SAH and dTDP-phenol
Method: X-RAY DIFFRACTION / Resolution: 1.3971 Å

PDB-6m83:
Crystal structure of TylM1 S120A bound to SAH and dTDP-phenol
Method: X-RAY DIFFRACTION / Resolution: 1.3685 Å

Chemicals

ChemComp-SAH:
S-ADENOSYL-L-HOMOCYSTEINE

ChemComp-TLO:
5'-O-[(S)-hydroxy{[(S)-hydroxy(phenoxy)phosphoryl]oxy}phosphoryl]thymidine

ChemComp-HOH:
WATER

ChemComp-EDO:
1,2-ETHANEDIOL

ChemComp-CL:
Unknown entry

Source
  • streptomyces fradiae (bacteria)
KeywordsTRANSFERASE / TylM1 / N-methyltransferase

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