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-Structure paper
Title | Discovery and optimization of novel piperazines as potent inhibitors of fatty acid synthase (FASN). |
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Journal, issue, pages | Bioorg. Med. Chem. Lett., Vol. 29, Page 1001-1006, Year 2019 |
Publish date | Jan 14, 2019 (structure data deposition date) |
Authors | Martin, M.W. / Lancia Jr., D.R. / Li, H. / Schiller, S.E.R. / Toms, A.V. / Wang, Z. / Bair, K.W. / Castro, J. / Fessler, S. / Gotur, D. ...Martin, M.W. / Lancia Jr., D.R. / Li, H. / Schiller, S.E.R. / Toms, A.V. / Wang, Z. / Bair, K.W. / Castro, J. / Fessler, S. / Gotur, D. / Hubbs, S.E. / Kauffman, G.S. / Kershaw, M. / Luke, G.P. / McKinnon, C. / Yao, L. / Lu, W. / Millan, D.S. |
External links | Bioorg. Med. Chem. Lett. / PubMed:30803804 |
Methods | X-ray diffraction |
Resolution | 2.26 Å |
Structure data | PDB-6nna: |
Chemicals | ChemComp-NDP: ChemComp-KUA: ChemComp-EDO: ChemComp-HOH: |
Source |
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Keywords | TRANSFERASE / FATTY ACID SYNTHASE / HUMAN FAS / KETO-REDUCTASE |