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Structure paper

TitleUnderstanding the role of intermolecular interactions between lissoclimides and the eukaryotic ribosome.
Journal, issue, pagesNucleic Acids Res., Vol. 47, Page 3223-3232, Year 2019
Publish dateAug 28, 2018 (structure data deposition date)
AuthorsPellegrino, S. / Meyer, M. / Konst, Z.A. / Holm, M. / Voora, V.K. / Kashinskaya, D. / Zanette, C. / Mobley, D.L. / Yusupova, G. / Vanderwal, C.D. ...Pellegrino, S. / Meyer, M. / Konst, Z.A. / Holm, M. / Voora, V.K. / Kashinskaya, D. / Zanette, C. / Mobley, D.L. / Yusupova, G. / Vanderwal, C.D. / Blanchard, S.C. / Yusupov, M.
External linksNucleic Acids Res. / PubMed:30759226
MethodsX-ray diffraction
Resolution3.10000049683 Å
Structure data

PDB-6hhq:
Crystal structure of compound C45 bound to the yeast 80S ribosome
Method: X-RAY DIFFRACTION / Resolution: 3.10000049683 Å

Chemicals

ChemComp-OHX:
osmium (III) hexammine

ChemComp-MG:
Unknown entry

ChemComp-G5B:
(3~{R})-3-[(1~{S})-2-[(1~{S},4~{a}~{R},6~{S},7~{S},8~{a}~{R})-6,7-bis(chloranyl)-5,5,8~{a}-trimethyl-2-methylidene-3,4,4~{a},6,7,8-hexahydro-1~{H}-naphthalen-1-yl]-1-oxidanyl-ethyl]pyrrolidine-2,5-dione

ChemComp-ZN:
Unknown entry

ChemComp-GOL:
GLYCEROL

Source
  • saccharomyces cerevisiae (brewer's yeast)
KeywordsRIBOSOME / 80S ribosome / inhibitor / anti-cancer

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