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Structure paper

TitleStructural and functional definition of a vulnerable site on the hemagglutinin of highly pathogenic avian influenza A virus H5N1.
Journal, issue, pagesJ. Biol. Chem., Vol. 294, Page 4290-4303, Year 2019
Publish dateNov 30, 2018 (structure data deposition date)
AuthorsWang, P. / Zuo, Y. / Sun, J. / Zuo, T. / Zhang, S. / Guo, S. / Shi, X. / Liang, M. / Zhou, P. / Zhang, L. / Wang, X.
External linksJ. Biol. Chem. / PubMed:30737282
MethodsX-ray diffraction
Resolution2.3 - 2.332 Å
Structure data

PDB-6iut:
Crystal structure of influenza A virus H5 hemagglutinin globular head in complex with the Fab of antibody AVFluIgG01
Method: X-RAY DIFFRACTION / Resolution: 2.3 Å

PDB-6iuv:
Crystal structure of influenza A virus H5 hemagglutinin globular head in complex with the Fab of antibody 3C11
Method: X-RAY DIFFRACTION / Resolution: 2.332 Å

Chemicals

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
  • influenza a virus (a/anhui/1/2005(h5n1))
  • influenza a virus (a/hong kong/482/97(h5n1))
KeywordsIMMUNE SYSTEM / influenza virus / HPAI / H5N1 / neutralizing antibody / epitope / major vulnerable site / vaccine development

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