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Structure paper

TitleStructural insights into FTO's catalytic mechanism for the demethylation of multiple RNA substrates.
Journal, issue, pagesProc. Natl. Acad. Sci. U.S.A., Vol. 116, Page 2919-2924, Year 2019
Publish dateApr 2, 2018 (structure data deposition date)
AuthorsZhang, X. / Wei, L.H. / Wang, Y. / Xiao, Y. / Liu, J. / Zhang, W. / Yan, N. / Amu, G. / Tang, X. / Zhang, L. / Jia, G.
External linksProc. Natl. Acad. Sci. U.S.A. / PubMed:30718435
MethodsX-ray diffraction
Resolution3.3 Å
Structure data

PDB-5zmd:
Crystal structure of FTO in complex with m6dA modified ssDNA
Method: X-RAY DIFFRACTION / Resolution: 3.3 Å

Chemicals

ChemComp-MN:
Unknown entry

ChemComp-OGA:
N-OXALYLGLYCINE / inhibitor*YM

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
  • dna launch vector pde-gfp2 (others)
KeywordsOXIDOREDUCTASE/DNA / RNA demetheylase FTO / m6A / substrate preference / RNA BINDING PROTEIN / OXIDOREDUCTASE-DNA complex

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