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Structure paper

TitleSuppression of Tumor Growth and Metastases by Targeted Intervention in Urokinase Activity with Cyclic Peptides.
Journal, issue, pagesJ. Med. Chem., Vol. 62, Page 2172-2183, Year 2019
Publish dateJul 8, 2018 (structure data deposition date)
AuthorsWang, D. / Yang, Y. / Jiang, L. / Wang, Y. / Li, J. / Andreasen, P.A. / Chen, Z. / Huang, M. / Xu, P.
External linksJ. Med. Chem. / PubMed:30707839
MethodsX-ray diffraction
Resolution2.489 - 2.53 Å
Structure data

PDB-6a8g:
The crystal structure of muPAin-1-IG in complex with muPA-SPD at pH8.5
Method: X-RAY DIFFRACTION / Resolution: 2.53 Å

PDB-6a8n:
The crystal structure of muPAin-1-IG-2 in complex with muPA-SPD at pH8.5
Method: X-RAY DIFFRACTION / Resolution: 2.489 Å

Chemicals

ChemComp-PO4:
PHOSPHATE ION

ChemComp-HOH:
WATER

Source
  • mus musculus (house mouse)
  • phage display vector ptdisp (others)
KeywordsHYDROLASE INHIBITOR/HYDROLASE / Peptides inhibitor / muPA / serine protease / HYDROLASE / HYDROLASE INHIBITOR-HYDROLASE complex / HYDROLASE/HYDROLASE INHIBITOR / HYDROLASE-HYDROLASE INHIBITOR complex

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