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TitleSelectivity, ligand deconstruction, and cellular activity analysis of a BPTF bromodomain inhibitor
Journal, issue, pagesOrg. Biomol. Chem., Vol. 17, Page 2020-2027, Year 2019
Publish dateAug 17, 2020 (structure data deposition date)
AuthorsKirberger, S.E. / Ycas, P.D. / Johnson, J.A. / Chen, C. / Ciccone, M.F. / Woo, R.W.L. / Urick, A.K. / Zahid, H. / Shi, K. / Aihara, H. ...Kirberger, S.E. / Ycas, P.D. / Johnson, J.A. / Chen, C. / Ciccone, M.F. / Woo, R.W.L. / Urick, A.K. / Zahid, H. / Shi, K. / Aihara, H. / McAllister, S.D. / Kashani-Sabet, M. / Shi, J. / Dickson, A. / Dos Santos, C.O. / Pomerantz, W.C.K.
External linksOrg. Biomol. Chem. / PubMed:30706071
MethodsX-ray diffraction
Resolution2.06 Å
Structure data

PDB-7jt4:
Crystal Structure of BPTF bromodomain labelled with 5-fluoro-tryptophan
Method: X-RAY DIFFRACTION / Resolution: 2.06 Å

Chemicals

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsGENE REGULATION / BPTF

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