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TitleMAA868, a novel FXI antibody with a unique binding mode, shows durable effects on markers of anticoagulation in humans.
Journal, issue, pagesBlood, Vol. 133, Page 1507-1516, Year 2019
Publish dateApr 2, 2019 (structure data deposition date)
AuthorsKoch, A.W. / Schiering, N. / Melkko, S. / Ewert, S. / Salter, J. / Zhang, Y. / McCormack, P. / Yu, J. / Huang, X. / Chiu, Y.H. ...Koch, A.W. / Schiering, N. / Melkko, S. / Ewert, S. / Salter, J. / Zhang, Y. / McCormack, P. / Yu, J. / Huang, X. / Chiu, Y.H. / Chen, Z. / Schleeger, S. / Horny, G. / DiPetrillo, K. / Muller, L. / Hein, A. / Villard, F. / Scharenberg, M. / Ramage, P. / Hassiepen, U. / Cote, S. / DeGagne, J. / Krantz, C. / Eder, J. / Stoll, B. / Kulmatycki, K. / Feldman, D.L. / Hoffmann, P. / Basson, C.T. / Frost, R.J.A. / Khder, Y.
External linksBlood / PubMed:30692123
MethodsX-ray diffraction
Resolution2.04 Å
Structure data

PDB-6r8x:
COAGULATION FACTOR XI CATALYTIC DOMAIN IN COMPLEX WITH FAB-PORTION OF MAA868
Method: X-RAY DIFFRACTION / Resolution: 2.04 Å

Chemicals

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
  • unidentified (others)
KeywordsBLOOD CLOTTING / Coagulation FXI / Zymogen / Antibody / Antagonist

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