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-Structure paper
Title | Fragment-Based Covalent Ligand Screening Enables Rapid Discovery of Inhibitors for the RBR E3 Ubiquitin Ligase HOIP. |
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Journal, issue, pages | J. Am. Chem. Soc., Vol. 141, Page 2703-2712, Year 2019 |
Publish date | Jul 5, 2018 (structure data deposition date) |
Authors | Johansson, H. / Isabella Tsai, Y.C. / Fantom, K. / Chung, C.W. / Kumper, S. / Martino, L. / Thomas, D.A. / Eberl, H.C. / Muelbaier, M. / House, D. / Rittinger, K. |
External links | J. Am. Chem. Soc. / PubMed:30657686 |
Methods | X-ray diffraction |
Resolution | 2.15 Å |
Structure data | PDB-6gzy: |
Chemicals | ChemComp-FHH: ChemComp-ZN: ChemComp-SO4: ChemComp-EDO: ChemComp-PGE: ChemComp-NA: ChemComp-HOH: |
Source |
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Keywords | LIGASE / Ubiquitin ligase / E3 / inhibitor complex |