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TitleEnhancing T cell responses and tumour immunity by vaccination with peptides conjugated to a weak NKT cell agonist.
Journal, issue, pagesOrg. Biomol. Chem., Vol. 17, Page 1225-1237, Year 2019
Publish dateMar 31, 2017 (structure data deposition date)
AuthorsCompton, B.J. / Farrand, K.J. / Tang, C.W. / Osmond, T.L. / Speir, M. / Authier-Hall, A. / Wang, J. / Ferguson, P.M. / Chan, S.T.S. / Anderson, R.J. ...Compton, B.J. / Farrand, K.J. / Tang, C.W. / Osmond, T.L. / Speir, M. / Authier-Hall, A. / Wang, J. / Ferguson, P.M. / Chan, S.T.S. / Anderson, R.J. / Cooney, T.R. / Hayman, C.M. / Williams, G.M. / Brimble, M.A. / Brooks, C.R. / Yong, L.K. / Metelitsa, L.S. / Zajonc, D.M. / Godfrey, D.I. / Gasser, O. / Weinkove, R. / Painter, G.F. / Hermans, I.F.
External linksOrg. Biomol. Chem. / PubMed:30656346
MethodsX-ray diffraction
Resolution3.16 Å
Structure data

PDB-5vcj:
Structure of alpha-galactosylphytosphingosine bound by CD1d and in complex with the Va14Vb8.2 TCR
Method: X-RAY DIFFRACTION / Resolution: 3.16 Å

Chemicals

ChemComp-N57:
(2S,3S,4R)-2-amino-3,4-dihydroxyoctadecyl alpha-D-galactopyranoside

ChemComp-PLM:
PALMITIC ACID

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

Source
  • mus musculus (house mouse)
  • homo sapiens (human)
KeywordsIMMUNE SYSTEM / antigen-presentation / TCR / MHC-fold

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