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Structure paper

TitleRecurrent activating mutations of PPAR gamma associated with luminal bladder tumors.
Journal, issue, pagesNat Commun, Vol. 10, Page 253-253, Year 2019
Publish dateMar 14, 2018 (structure data deposition date)
AuthorsRochel, N. / Krucker, C. / Coutos-Thevenot, L. / Osz, J. / Zhang, R. / Guyon, E. / Zita, W. / Vanthong, S. / Hernandez, O.A. / Bourguet, M. ...Rochel, N. / Krucker, C. / Coutos-Thevenot, L. / Osz, J. / Zhang, R. / Guyon, E. / Zita, W. / Vanthong, S. / Hernandez, O.A. / Bourguet, M. / Badawy, K.A. / Dufour, F. / Peluso-Iltis, C. / Heckler-Beji, S. / Dejaegere, A. / Kamoun, A. / de Reynies, A. / Neuzillet, Y. / Rebouissou, S. / Beraud, C. / Lang, H. / Massfelder, T. / Allory, Y. / Cianferani, S. / Stote, R.H. / Radvanyi, F. / Bernard-Pierrot, I.
External linksNat Commun / PubMed:30651555
MethodsX-ray diffraction
Resolution1.95 - 3.1 Å
Structure data

PDB-6fzf:
PPAR mutant complex
Method: X-RAY DIFFRACTION / Resolution: 1.95 Å

PDB-6fzg:
PPAR gamma mutant complex
Method: X-RAY DIFFRACTION / Resolution: 2.1 Å

PDB-6fzj:
PPAR gamma mutant complex
Method: X-RAY DIFFRACTION / Resolution: 2.011 Å

PDB-6fzp:
PPAR gamma complex.
Method: X-RAY DIFFRACTION / Resolution: 2.3 Å

PDB-6fzy:
PPAR mutant
Method: X-RAY DIFFRACTION / Resolution: 3.1 Å

Chemicals

ChemComp-EDK:
(2~{S})-3-[4-[2-[methyl(pyridin-2-yl)amino]ethoxy]phenyl]-2-[[2-(phenylcarbonyl)phenyl]amino]propanoic acid

ChemComp-HOH:
WATER

ChemComp-CL:
Unknown entry

ChemComp-IOD:
IODIDE ION

Source
  • homo sapiens (human)
KeywordsTRANSCRIPTION / nuclear receptor

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