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Structure paper

TitleThe Translation Inhibitor Rocaglamide Targets a Bimolecular Cavity between eIF4A and Polypurine RNA.
Journal, issue, pagesMol. Cell, Vol. 73, Page 738-, Year 2019
Publish dateFeb 16, 2018 (structure data deposition date)
AuthorsIwasaki, S. / Iwasaki, W. / Takahashi, M. / Sakamoto, A. / Watanabe, C. / Shichino, Y. / Floor, S.N. / Fujiwara, K. / Mito, M. / Dodo, K. ...Iwasaki, S. / Iwasaki, W. / Takahashi, M. / Sakamoto, A. / Watanabe, C. / Shichino, Y. / Floor, S.N. / Fujiwara, K. / Mito, M. / Dodo, K. / Sodeoka, M. / Imataka, H. / Honma, T. / Fukuzawa, K. / Ito, T. / Ingolia, N.T.
External linksMol. Cell / PubMed:30595437
MethodsX-ray diffraction
Resolution2 Å
Structure data

PDB-5zc9:
Crystal structure of the human eIF4A1-ATP analog-RocA-polypurine RNA complex
Method: X-RAY DIFFRACTION / Resolution: 2 Å

Chemicals

ChemComp-ANP:
PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER / AMP-PNP, energy-carrying molecule analogue*YM

ChemComp-MG:
Unknown entry

ChemComp-RCG:
(1R,2R,3S,3aR,8bS)-6,8-dimethoxy-3a-(4-methoxyphenyl)-N,N-dimethyl-1,8b-bis(oxidanyl)-3-phenyl-2,3-dihydro-1H-cyclopenta[b][1]benzofuran-2-carboxamide

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
  • synthetic construct (others)
KeywordsTRANSLATION/RNA / INITIATION FACTOR / DEAD-BOX / HELICASE / PROTEIN-RNA COMPLEX / ATPase / ROCAGLAMIDE A / ANTICANCER COMPOUND / TRANSLATION / TRANSLATION-RNA complex

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