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Title | Development of alkyl glycerone phosphate synthase inhibitors: Structure-activity relationship and effects on ether lipids and epithelial-mesenchymal transition in cancer cells. |
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Journal, issue, pages | Eur J Med Chem, Vol. 163, Page 722-735, Year 2018 |
Publish date | Jun 4, 2018 (structure data deposition date) |
![]() | Stazi, G. / Battistelli, C. / Piano, V. / Mazzone, R. / Marrocco, B. / Marchese, S. / Louie, S.M. / Zwergel, C. / Antonini, L. / Patsilinakos, A. ...Stazi, G. / Battistelli, C. / Piano, V. / Mazzone, R. / Marrocco, B. / Marchese, S. / Louie, S.M. / Zwergel, C. / Antonini, L. / Patsilinakos, A. / Ragno, R. / Viviano, M. / Sbardella, G. / Ciogli, A. / Fabrizi, G. / Cirilli, R. / Strippoli, R. / Marchetti, A. / Tripodi, M. / Nomura, D.K. / Mattevi, A. / Mai, A. / Valente, S. |
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Methods | X-ray diffraction |
Resolution | 2.9 Å |
Structure data | ![]() PDB-6gou: |
Chemicals | ![]() ChemComp-FAD: ![]() ChemComp-F6T: |
Source |
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![]() | FLAVOPROTEIN / Ether phospholipids / catalytic mechanism / inhibitor / anti-cancer |