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TitleDevelopment, Optimization, and Structural Characterization of an Efficient Peptide-Based Photoaffinity Cross-Linking Reaction for Generation of Homogeneous Conjugates from Wild-Type Antibodies.
Journal, issue, pagesBioconjug. Chem., Vol. 30, Page 148-160, Year 2019
Publish dateDec 4, 2018 (structure data deposition date)
AuthorsVance, N. / Zacharias, N. / Ultsch, M. / Li, G. / Fourie, A. / Liu, P. / LaFrance-Vanasse, J. / Ernst, J.A. / Sandoval, W. / Kozak, K.R. ...Vance, N. / Zacharias, N. / Ultsch, M. / Li, G. / Fourie, A. / Liu, P. / LaFrance-Vanasse, J. / Ernst, J.A. / Sandoval, W. / Kozak, K.R. / Phillips, G. / Wang, W. / Sadowsky, J.
External linksBioconjug. Chem. / PubMed:30566343
MethodsX-ray diffraction
Resolution2.576 Å
Structure data

PDB-6n9t:
Structure of a peptide-based photo-affinity cross-linker with Herceptin Fc
Method: X-RAY DIFFRACTION / Resolution: 2.576 Å

Chemicals

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
  • synthetic construct (others)
KeywordsIMMUNE SYSTEM / Crosslinking / antibody / photo-reactive

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