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Structure paper

TitleThe crystal structure of a tetrahydrofolate-bound dihydrofolate reductase reveals the origin of slow product release.
Journal, issue, pagesCommun Biol, Vol. 1, Page 226-226, Year 2018
Publish dateMar 14, 2018 (structure data deposition date)
AuthorsCao, H. / Gao, M. / Zhou, H. / Skolnick, J.
External linksCommun Biol / PubMed:30564747
MethodsX-ray diffraction
Resolution1.03 - 2.2 Å
Structure data

PDB-6cqa:
E. coli DHFR complex with inhibitor AMPQD
Method: X-RAY DIFFRACTION / Resolution: 2.2 Å

PDB-6cw7:
E. coli DHFR product complex with (6S)-5,6,7,8-TETRAHYDROFOLATE
Method: X-RAY DIFFRACTION / Resolution: 1.03 Å

PDB-6cxk:
E. coli DHFR substrate complex with Dihydrofolate
Method: X-RAY DIFFRACTION / Resolution: 1.108 Å

PDB-6cyv:
E. coli DHFR ternary complex with NADP and dihydrofolate
Method: X-RAY DIFFRACTION / Resolution: 1.3 Å

Chemicals

ChemComp-SO4:
SULFATE ION

ChemComp-PQD:
7-[(3-aminophenyl)methyl]-7H-pyrrolo[3,2-f]quinazoline-1,3-diamine

ChemComp-HOH:
WATER

ChemComp-THG:
(6S)-5,6,7,8-TETRAHYDROFOLATE

ChemComp-CL:
Unknown entry

ChemComp-MG:
Unknown entry

ChemComp-DHF:
DIHYDROFOLIC ACID

ChemComp-NAP:
NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE

Source
  • escherichia coli (E. coli)
  • escherichia coli o6:h1 (strain cft073 / atcc 700928 / upec) (bacteria)
KeywordsOXIDOREDUCTASE / DHFR / dihydrofolate reductase / inhibitor / complex / tetrahydrofolate / dihydrofolate / NADP / ternary complex

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