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TitleV2-Directed Vaccine-like Antibodies from HIV-1 Infection Identify an Additional K169-Binding Light Chain Motif with Broad ADCC Activity.
Journal, issue, pagesCell Rep, Vol. 25, Page 3123-3135.e6, Year 2018
Publish dateMar 10, 2018 (structure data deposition date)
Authorsvan Eeden, C. / Wibmer, C.K. / Scheepers, C. / Richardson, S.I. / Nonyane, M. / Lambson, B. / Mkhize, N.N. / Vijayakumar, B. / Sheng, Z. / Stanfield-Oakley, S. ...van Eeden, C. / Wibmer, C.K. / Scheepers, C. / Richardson, S.I. / Nonyane, M. / Lambson, B. / Mkhize, N.N. / Vijayakumar, B. / Sheng, Z. / Stanfield-Oakley, S. / Bhiman, J.N. / Bekker, V. / Hermanus, T. / Mabvakure, B. / Ismail, A. / Moody, M.A. / Wiehe, K. / Garrett, N. / Karim, S.A. / Dirr, H. / Fernandes, M.A. / Sayed, Y. / Shapiro, L. / Ferrari, G. / Haynes, B.F. / Moore, P.L. / Morris, L.
External linksCell Rep / PubMed:30540944
MethodsX-ray diffraction
Resolution2.57 Å
Structure data

PDB-6fy0:
Crystal structure of a V2-directed, RV144 vaccine-like antibody from HIV-1 infection, CAP228-16H, bound to a heterologous V2 peptide
Method: X-RAY DIFFRACTION / Resolution: 2.57 Å

Chemicals

ChemComp-SO4:
SULFATE ION

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
  • human immunodeficiency virus 1
KeywordsIMMUNE SYSTEM / Fab / HIV V2 peptide

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