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TitleIterative Design and Optimization of Initially Inactive Proteolysis Targeting Chimeras (PROTACs) Identify VZ185 as a Potent, Fast, and Selective von Hippel-Lindau (VHL) Based Dual Degrader Probe of BRD9 and BRD7.
Journal, issue, pagesJ. Med. Chem., Vol. 62, Page 699-726, Year 2019
Publish dateSep 11, 2018 (structure data deposition date)
AuthorsZoppi, V. / Hughes, S.J. / Maniaci, C. / Testa, A. / Gmaschitz, T. / Wieshofer, C. / Koegl, M. / Riching, K.M. / Daniels, D.L. / Spallarossa, A. / Ciulli, A.
External linksJ. Med. Chem. / PubMed:30540463
MethodsX-ray diffraction
Resolution2.4 Å
Structure data

PDB-6hm0:
Crystal structure of human BRD9 bromodomain in complex with a PROTAC
Method: X-RAY DIFFRACTION / Resolution: 2.4 Å

Chemicals

ChemComp-GBW:
(2~{S},4~{S})-1-[(2~{S})-2-[2-[2-[2-[4-[[2,6-dimethoxy-4-(2-methyl-1-oxidanylidene-2,7-naphthyridin-4-yl)phenyl]methyl]piperazin-1-yl]ethoxy]ethoxy]ethanoylamino]-3,3-dimethyl-butanoyl]-~{N}-[[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl]-4-oxidanyl-pyrrolidine-2-carboxamide

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSCRIPTION / PROTAC / LYSINE-ACETYLATED HISTONE BINDING / CHROMATIN REGULATOR

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