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TitleRational design of 5-((1H-imidazol-1-yl)methyl)quinolin-8-ol derivatives as novel bromodomain-containing protein 4 inhibitors
Journal, issue, pagesEur J Med Chem, Vol. 163, Page 281-294, Year 2018
Publish dateAug 8, 2018 (structure data deposition date)
AuthorsXing, J. / Zhang, R. / Jiang, X. / Hu, T. / Wang, X. / Qiao, G. / Wang, J. / Yang, F. / Luo, X. / Chen, K. ...Xing, J. / Zhang, R. / Jiang, X. / Hu, T. / Wang, X. / Qiao, G. / Wang, J. / Yang, F. / Luo, X. / Chen, K. / Shen, J. / Luo, C. / Jiang, H. / Zheng, M.
External linksEur J Med Chem / PubMed:30529546
MethodsX-ray diffraction
Resolution1.998 Å
Structure data

PDB-6afr:
Crystal Structure of the first bromodomain of human BRD4 in complex with 5-((4-fluoro-1H-imidazol-1-yl)methyl)quinolin-8-ol
Method: X-RAY DIFFRACTION / Resolution: 1.998 Å

Chemicals

ChemComp-9E3:
5-[(4-fluoranylimidazol-1-yl)methyl]quinolin-8-ol

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsSignaling protein/inhibitor / Brd4 / epigenetic / SIGNALING PROTEIN-INHIBITOR complex

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