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TitleHighly Potent and Selective Plasmin Inhibitors Based on the Sunflower Trypsin Inhibitor-1 Scaffold Attenuate Fibrinolysis in Plasma.
Journal, issue, pagesJ. Med. Chem., Vol. 62, Page 552-560, Year 2019
Publish dateApr 17, 2018 (structure data deposition date)
AuthorsSwedberg, J.E. / Wu, G. / Mahatmanto, T. / Durek, T. / Caradoc-Davies, T.T. / Whisstock, J.C. / Law, R.H.P. / Craik, D.J.
External linksJ. Med. Chem. / PubMed:30520638
MethodsX-ray diffraction
Resolution1.32 - 2 Å
Structure data

PDB-6d3x:
Highly Potent and Selective Plasmin Inhibitors Based on the Sunflower Trypsin Inhibitor-1 Scaffold Attenuate Fibrinolysis in Plasma
Method: X-RAY DIFFRACTION / Resolution: 1.8 Å

PDB-6d3y:
Highly Potent and Selective Plasmin Inhibitors Based on the Sunflower Trypsin Inhibitor-1 Scaffold Attenuate Fibrinolysis in Plasma
Method: X-RAY DIFFRACTION / Resolution: 1.32 Å

PDB-6d3z:
Protease SFTI complex
Method: X-RAY DIFFRACTION / Resolution: 2 Å

PDB-6d40:
Highly Potent and Selective Plasmin Inhibitors Based on the Sunflower Trypsin Inhibitor-1 Scaffold Attenuate Fibrinolysis in Plasma
Method: X-RAY DIFFRACTION / Resolution: 1.43 Å

Chemicals

ChemComp-HOH:
WATER

ChemComp-SO4:
SULFATE ION

ChemComp-GOL:
GLYCEROL

Source
  • homo sapiens (human)
  • helianthus annuus (common sunflower)
KeywordsHYDROLASE / Protease / SFTI / complex / proteases / fibrinolysis / BLOOD CLOTTING

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