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TitleAn engineered lipocalin that tightly complexes the plant poison colchicine for use as antidote and in bioanalytical applications.
Journal, issue, pagesBiol. Chem., Vol. 400, Page 351-366, Year 2019
Publish dateMar 31, 2017 (structure data deposition date)
AuthorsBarkovskiy, M. / Ilyukhina, E. / Dauner, M. / Eichinger, A. / Skerra, A.
External linksBiol. Chem. / PubMed:30517073
MethodsX-ray diffraction
Resolution2.2 Å
Structure data

PDB-5nkn:
Crystal structure of an Anticalin-colchicine complex
Method: X-RAY DIFFRACTION / Resolution: 2.2 Å

Chemicals

ChemComp-LOC:
N-[(7S)-1,2,3,10-tetramethoxy-9-oxo-6,7-dihydro-5H-benzo[d]heptalen-7-yl]ethanamide / medication, antiinflammatory*YM

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSPORT PROTEIN / beta-barrel / colchicine / Lcn2 / lipocalin / NGAL / protein engineering

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