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TitleTargeted Synthesis of Complex Spiro[3H-indole-3,2'-pyrrolidin]-2(1H)-ones by Intramolecular Cyclization of Azomethine Ylides: Highly Potent MDM2-p53 Inhibitors.
Journal, issue, pagesChemMedChem, Vol. 14, Page 88-93, Year 2019
Publish dateNov 7, 2018 (structure data deposition date)
AuthorsGollner, A. / Weinstabl, H. / Fuchs, J.E. / Rudolph, D. / Garavel, G. / Hofbauer, K.S. / Karolyi-Oezguer, J. / Gmaschitz, G. / Hela, W. / Kerres, N. ...Gollner, A. / Weinstabl, H. / Fuchs, J.E. / Rudolph, D. / Garavel, G. / Hofbauer, K.S. / Karolyi-Oezguer, J. / Gmaschitz, G. / Hela, W. / Kerres, N. / Grondal, E. / Werni, P. / Ramharter, J. / Broeker, J. / McConnell, D.B.
External linksChemMedChem / PubMed:30458062
MethodsX-ray diffraction
Resolution1.77 Å
Structure data

PDB-6i3s:
Crystal structure of MDM2 in complex with compound 13.
Method: X-RAY DIFFRACTION / Resolution: 1.77 Å

Chemicals

ChemComp-H28:
(3~{S},3'~{R},3'~{a}~{S},6'~{a}~{R})-6-chloranyl-3'-(3-chloranyl-2-fluoranyl-phenyl)-1'-(cyclopropylmethyl)spiro[1~{H}-indole-3,2'-3~{a},6~{a}-dihydro-3~{H}-pyrrolo[3,4-b]pyrrole]-2,4'-dione

ChemComp-GOL:
GLYCEROL

ChemComp-SO4:
SULFATE ION

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsLIGASE / Inhibitor

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