+Search query
-Structure paper
Title | Novel multitarget-directed ligands targeting acetylcholinesterase and sigma1receptors as lead compounds for treatment of Alzheimer's disease: Synthesis, evaluation, and structural characterization of their complexes with acetylcholinesterase. |
---|---|
Journal, issue, pages | Eur J Med Chem, Vol. 162, Page 234-248, Year 2018 |
Publish date | Nov 15, 2017 (structure data deposition date) |
Authors | Lalut, J. / Santoni, G. / Karila, D. / Lecoutey, C. / Davis, A. / Nachon, F. / Silman, I. / Sussman, J. / Weik, M. / Maurice, T. ...Lalut, J. / Santoni, G. / Karila, D. / Lecoutey, C. / Davis, A. / Nachon, F. / Silman, I. / Sussman, J. / Weik, M. / Maurice, T. / Dallemagne, P. / Rochais, C. |
External links | Eur J Med Chem / PubMed:30447434 |
Methods | X-ray diffraction |
Resolution | 2.2 - 2.6 Å |
Structure data | PDB-6ezg: PDB-6ezh: |
Chemicals | ChemComp-NAG: ChemComp-C6K: ChemComp-PEG: ChemComp-HOH: ChemComp-C6H: |
Source |
|
Keywords | HYDROLASE / Acetylcholinesterase / Multi-target inhibitor / Alzheimer desease |