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Title | Novel multitarget-directed ligands targeting acetylcholinesterase and sigma1receptors as lead compounds for treatment of Alzheimer's disease: Synthesis, evaluation, and structural characterization of their complexes with acetylcholinesterase. |
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Journal, issue, pages | Eur J Med Chem, Vol. 162, Page 234-248, Year 2018 |
Publish date | Nov 15, 2017 (structure data deposition date) |
![]() | Lalut, J. / Santoni, G. / Karila, D. / Lecoutey, C. / Davis, A. / Nachon, F. / Silman, I. / Sussman, J. / Weik, M. / Maurice, T. ...Lalut, J. / Santoni, G. / Karila, D. / Lecoutey, C. / Davis, A. / Nachon, F. / Silman, I. / Sussman, J. / Weik, M. / Maurice, T. / Dallemagne, P. / Rochais, C. |
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Methods | X-ray diffraction |
Resolution | 2.2 - 2.6 Å |
Structure data | ![]() PDB-6ezg: ![]() PDB-6ezh: |
Chemicals | ![]() ChemComp-NAG: ![]() ChemComp-C6K: ![]() ChemComp-PEG: ![]() ChemComp-HOH: ![]() ChemComp-C6H: |
Source |
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![]() | HYDROLASE / Acetylcholinesterase / Multi-target inhibitor / Alzheimer desease |