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TitleRIP1 Kinase Drives Macrophage-Mediated Adaptive Immune Tolerance in Pancreatic Cancer.
Journal, issue, pagesCancer Cell, Vol. 34, Page 757-774.e7, Year 2018
Publish dateAug 28, 2018 (structure data deposition date)
AuthorsWang, W. / Marinis, J.M. / Beal, A.M. / Savadkar, S. / Wu, Y. / Khan, M. / Taunk, P.S. / Wu, N. / Su, W. / Wu, J. ...Wang, W. / Marinis, J.M. / Beal, A.M. / Savadkar, S. / Wu, Y. / Khan, M. / Taunk, P.S. / Wu, N. / Su, W. / Wu, J. / Ahsan, A. / Kurz, E. / Chen, T. / Yaboh, I. / Li, F. / Gutierrez, J. / Diskin, B. / Hundeyin, M. / Reilly, M. / Lich, J.D. / Harris, P.A. / Mahajan, M.K. / Thorpe, J.H. / Nassau, P. / Mosley, J.E. / Leinwand, J. / Kochen Rossi, J.A. / Mishra, A. / Aykut, B. / Glacken, M. / Ochi, A. / Verma, N. / Kim, J.I. / Vasudevaraja, V. / Adeegbe, D. / Almonte, C. / Bagdatlioglu, E. / Cohen, D.J. / Wong, K.K. / Bertin, J. / Miller, G.
External linksCancer Cell / PubMed:30423296
MethodsX-ray diffraction
Resolution3.49 Å
Structure data

PDB-6hho:
Crystal structure of RIP1 kinase in complex with GSK547
Method: X-RAY DIFFRACTION / Resolution: 3.49 Å

Chemicals

ChemComp-G4W:
6-[4-[(5~{S})-5-[3,5-bis(fluoranyl)phenyl]pyrazolidin-1-yl]carbonylpiperidin-1-yl]pyrimidine-4-carbonitrile

Source
  • homo sapiens (human)
KeywordsTRANSFERASE / Inhibitor

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