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Structure paper

TitleEngineering Improved Antiphosphotyrosine Antibodies Based on an Immunoconvergent Binding Motif.
Journal, issue, pagesJ. Am. Chem. Soc., Vol. 140, Page 16615-16624, Year 2018
Publish dateMay 13, 2018 (structure data deposition date)
AuthorsMou, Y. / Zhou, X.X. / Leung, K. / Martinko, A.J. / Yu, J.Y. / Chen, W. / Wells, J.A.
External linksJ. Am. Chem. Soc. / PubMed:30398859
MethodsX-ray diffraction
Resolution2.3 - 3.2 Å
Structure data

PDB-6dez:
Anti-phosphotyrosine antibody PY20-4D5 Fab complexed with sulfate
Method: X-RAY DIFFRACTION / Resolution: 3.2 Å

PDB-6df0:
anti-phosphotyrosine antibody 4G10-4D5 Fab complexed with sulfate
Method: X-RAY DIFFRACTION / Resolution: 2.3 Å

PDB-6df1:
Anti-phosphotyrosine antibody 4G10-4D5 Fab complexed with phosphotyrosine peptide
Method: X-RAY DIFFRACTION / Resolution: 2.3 Å

PDB-6df2:
Improved anti-phosphotyrosine antibody 4G10-S5-4D5 Fab complexed with phosphotyrosine peptide
Method: X-RAY DIFFRACTION / Resolution: 2.6 Å

Chemicals

ChemComp-SO4:
SULFATE ION

ChemComp-HOH:
WATER

Source
  • synthetic construct (others)
  • homo sapiens (human)
KeywordsIMMUNE SYSTEM / Antibody / RECOMBINATION

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