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Structure paper

TitleStructural insights into the pi-pi-pi stacking mechanism and DNA-binding activity of the YEATS domain.
Journal, issue, pagesNat Commun, Vol. 9, Page 4574-4574, Year 2018
Publish dateSep 19, 2018 (structure data deposition date)
AuthorsKlein, B.J. / Vann, K.R. / Andrews, F.H. / Wang, W.W. / Zhang, J. / Zhang, Y. / Beloglazkina, A.A. / Mi, W. / Li, Y. / Li, H. ...Klein, B.J. / Vann, K.R. / Andrews, F.H. / Wang, W.W. / Zhang, J. / Zhang, Y. / Beloglazkina, A.A. / Mi, W. / Li, Y. / Li, H. / Shi, X. / Kutateladze, A.G. / Strahl, B.D. / Liu, W.R. / Kutateladze, T.G.
External linksNat Commun / PubMed:30385749
MethodsX-ray diffraction
Resolution1.75 - 2.525 Å
Structure data

PDB-6mil:
Crystal structure of AF9 YEATS domain in complex with histone H3K9bu
Method: X-RAY DIFFRACTION / Resolution: 1.93 Å

PDB-6mim:
Crystal structure of AF9 YEATS domain Y78W mutant in complex with histone H3K9cr
Method: X-RAY DIFFRACTION / Resolution: 2.525 Å

PDB-6min:
Crystal structure of Taf14 YEATS domain G82A mutant in complex with histone H3K9cr
Method: X-RAY DIFFRACTION / Resolution: 1.9 Å

PDB-6mio:
Crystal structure of Taf14 YEATS domain in complex with histone H3K9pr
Method: X-RAY DIFFRACTION / Resolution: 1.85 Å

PDB-6mip:
Crystal structure of Taf14 YEATS domain G82A mutant
Method: X-RAY DIFFRACTION / Resolution: 2 Å

PDB-6miq:
Crystal structure of Taf14 YEATS domain in complex with histone H3K9bu
Method: X-RAY DIFFRACTION / Resolution: 1.75 Å

Chemicals

ChemComp-PEG:
DI(HYDROXYETHYL)ETHER

ChemComp-MLI:
MALONATE ION

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
  • saccharomyces cerevisiae (strain atcc 204508 / s288c) (yeast)
KeywordsTRANSCRIPTION / Epigenetic / Histone reader

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