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TitleDiscovery of Tarantula Venom-Derived NaV1.7-Inhibitory JzTx-V Peptide 5-Br-Trp24 Analogue AM-6120 with Systemic Block of Histamine-Induced Pruritis.
Journal, issue, pagesJ. Med. Chem., Vol. 61, Page 9500-9512, Year 2018
Publish dateMar 9, 2018 (structure data deposition date)
AuthorsWu, B. / Murray, J.K. / Andrews, K.L. / Sham, K. / Long, J. / Aral, J. / Ligutti, J. / Amagasu, S. / Liu, D. / Zou, A. ...Wu, B. / Murray, J.K. / Andrews, K.L. / Sham, K. / Long, J. / Aral, J. / Ligutti, J. / Amagasu, S. / Liu, D. / Zou, A. / Min, X. / Wang, Z. / Ilch, C.P. / Kornecook, T.J. / Lin, M.J. / Be, X. / Miranda, L.P. / Moyer, B.D. / Biswas, K.
External linksJ. Med. Chem. / PubMed:30346167
MethodsX-ray diffraction
Resolution1.05 Å
Structure data

PDB-6cnu:
Crystal Structure of JzTX-V
Method: X-RAY DIFFRACTION / Resolution: 1.05 Å

Chemicals

ChemComp-BR:
BROMIDE ION

ChemComp-SO4:
SULFATE ION

ChemComp-GOL:
GLYCEROL

ChemComp-HOH:
WATER

Source
  • chilobrachys guangxiensis (spider)
KeywordsTOXIN / inhibitor cysteine knot

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