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TitleDimethyl fumarate is an allosteric covalent inhibitor of the p90 ribosomal S6 kinases.
Journal, issue, pagesNat Commun, Vol. 9, Page 4344-4344, Year 2018
Publish dateMay 19, 2017 (structure data deposition date)
AuthorsAndersen, J.L. / Gesser, B. / Funder, E.D. / Nielsen, C.J.F. / Gotfred-Rasmussen, H. / Rasmussen, M.K. / Toth, R. / Gothelf, K.V. / Arthur, J.S.C. / Iversen, L. / Nissen, P.
External linksNat Commun / PubMed:30341347
MethodsX-ray diffraction
Resolution1.9 Å
Structure data

PDB-5o1s:
Dimethyl fumarate is an allosteric covalent inhibitor of the p90 ribosomal S6 kinases
Method: X-RAY DIFFRACTION / Resolution: 1.9 Å

Chemicals

ChemComp-NA:
Unknown entry

ChemComp-9HB:
Dimethyl fumarate

ChemComp-HOH:
WATER

Source
  • mus musculus (house mouse)
KeywordsTRANSFERASE / Covalent / Inhibitor / Kinase / allosteric

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