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TitleHigh-resolution glycosylation site-engineering method identifies MICA epitope critical for shedding inhibition activity of anti-MICA antibodies.
Journal, issue, pagesMAbs, Vol. 11, Page 75-93, Year 2019
Publish dateMay 10, 2018 (structure data deposition date)
AuthorsLombana, T.N. / Matsumoto, M.L. / Berkley, A.M. / Toy, E. / Cook, R. / Gan, Y. / Du, C. / Schnier, P. / Sandoval, W. / Ye, Z. ...Lombana, T.N. / Matsumoto, M.L. / Berkley, A.M. / Toy, E. / Cook, R. / Gan, Y. / Du, C. / Schnier, P. / Sandoval, W. / Ye, Z. / Schartner, J.M. / Kim, J. / Spiess, C.
External linksMAbs / PubMed:30307368
MethodsX-ray diffraction
Resolution1.3 - 2.05 Å
Structure data

PDB-6ddm:
Crystal Structure Analysis of the Epitope of an Anti-MICA Antibody
Method: X-RAY DIFFRACTION / Resolution: 1.3 Å

PDB-6ddr:
Crystal Structure Analysis of the Epitope of an Anti-MICA Antibody
Method: X-RAY DIFFRACTION / Resolution: 1.9 Å

PDB-6ddv:
Crystal Structure Analysis of the Epitope of an Anti-MICA Antibody
Method: X-RAY DIFFRACTION / Resolution: 2.05 Å

Chemicals

ChemComp-HOH:
WATER

ChemComp-GOL:
GLYCEROL

ChemComp-SO4:
SULFATE ION

ChemComp-ZN:
Unknown entry

Source
  • mus musculus (house mouse)
  • homo sapiens (human)
KeywordsIMMUNE SYSTEM / Fab fragment-antigen complex / immunoglobulin domain

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