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TitleInhibiting amyloid-beta cytotoxicity through its interaction with the cell surface receptor LilrB2 by structure-based design.
Journal, issue, pagesNat Chem, Vol. 10, Page 1213-1221, Year 2018
Publish dateOct 20, 2017 (structure data deposition date)
AuthorsCao, Q. / Shin, W.S. / Chan, H. / Vuong, C.K. / Dubois, B. / Li, B. / Murray, K.A. / Sawaya, M.R. / Feigon, J. / Black, D.L. ...Cao, Q. / Shin, W.S. / Chan, H. / Vuong, C.K. / Dubois, B. / Li, B. / Murray, K.A. / Sawaya, M.R. / Feigon, J. / Black, D.L. / Eisenberg, D.S. / Jiang, L.
External linksNat Chem / PubMed:30297750
MethodsX-ray diffraction
Resolution2.1 Å
Structure data

PDB-6bcs:
LilrB2 D1D2 domains complexed with benzamidine
Method: X-RAY DIFFRACTION / Resolution: 2.1 Å

Chemicals

ChemComp-BEN:
BENZAMIDINE

ChemComp-CL:
Unknown entry

ChemComp-DMS:
DIMETHYL SULFOXIDE / DMSO, precipitant*YM

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsIMMUNE SYSTEM / receptor / IG LIKE DOMAINS

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