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Structure paper

TitleHigh-resolution crystal structures of the D1 and D2 domains of protein tyrosine phosphatase epsilon for structure-based drug design.
Journal, issue, pagesActa Crystallogr D Struct Biol, Vol. 74, Page 1015-1026, Year 2018
Publish dateApr 16, 2018 (structure data deposition date)
AuthorsLountos, G.T. / Raran-Kurussi, S. / Zhao, B.M. / Dyas, B.K. / Burke Jr., T.R. / Ulrich, R.G. / Waugh, D.S.
External linksActa Crystallogr D Struct Biol / PubMed:30289412
MethodsX-ray diffraction
Resolution1.765 - 2.271 Å
Structure data

PDB-6d3f:
Crystal Structure of the PTP epsilon D2 domain
Method: X-RAY DIFFRACTION / Resolution: 2.271 Å

PDB-6d4d:
Crystal structure of the PTP epsilon D1 domain
Method: X-RAY DIFFRACTION / Resolution: 1.765 Å

PDB-6d4f:
Crystal structure of PTP epsilon D2 domain (A455N/V457Y/E597D)
Method: X-RAY DIFFRACTION / Resolution: 1.909 Å

Chemicals

ChemComp-HOH:
WATER

ChemComp-1PE:
PENTAETHYLENE GLYCOL / precipitant*YM

Source
  • homo sapiens (human)
KeywordsHYDROLASE / phosphatase

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