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TitleReviving B-Factors: Activating ALK Mutations Increase Protein Dynamics of the Unphosphorylated Kinase.
Journal, issue, pagesACS Med Chem Lett, Vol. 9, Page 872-877, Year 2018
Publish dateFeb 9, 2018 (structure data deposition date)
AuthorsJohnson, T.W. / Bolanos, B. / Brooun, A. / Gallego, R.A. / Gehlhaar, D. / Jalaie, M. / McTigue, M. / Timofeevski, S.
External linksACS Med Chem Lett / PubMed:30258533
MethodsX-ray diffraction
Resolution1.8 Å
Structure data

PDB-6cdt:
Structure of Human Anaplastic Lymphoma Kinase Domain
Method: X-RAY DIFFRACTION / Resolution: 1.8 Å

Chemicals

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSFERASE / kinase

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