EMDB/PDB/SASBDBから引用されている文献のデータベース

キーワード
構造解析手法	All X線回折 NMR 電子顕微鏡小角散乱中性子線回折線維回折粉末回折赤外分光 EPR FRET 理論モデルハイブリッド
著者・登録者
ジャーナル
IF	>30 >20 >10 >5 all

タイトル	Commercial AHAS-inhibiting herbicides are promising drug leads for the treatment of human fungal pathogenic infections.
ジャーナル・号・ページ	Proc. Natl. Acad. Sci. U.S.A., Vol. 115, Page E9649-E9658, Year 2018
掲載日	2018年5月12日 (構造データの登録日)
著者	Garcia, M.D. / Chua, S.M.H. / Low, Y.S. / Lee, Y.T. / Agnew-Francis, K. / Wang, J.G. / Nouwens, A. / Lonhienne, T. / Williams, C.M. / Fraser, J.A. / Guddat, L.W.
リンク	Proc. Natl. Acad. Sci. U.S.A. / PubMed:30249642
手法	X線回折
解像度	1.806 - 2.971 Å
構造データ	PDB-6dek: Crystal structure of Candida albicans acetohydroxyacid synthase catalytic subunit 手法: X-RAY DIFFRACTION / 解像度: 2.971 Å PDB-6del: Crystal structure of Candida albicans acetohydroxyacid synthase in complex with the herbicide chlorimuron ethyl 手法: X-RAY DIFFRACTION / 解像度: 2.119 Å PDB-6dem: Crystal structure of Candida albicans acetohydroxyacid synthase in complex with the herbicide bensulfuron methyl 手法: X-RAY DIFFRACTION / 解像度: 2.038 Å PDB-6den: Crystal structure of Candida albicans acetohydroxyacid synthase in complex with the herbicide iodomuron ethyl 手法: X-RAY DIFFRACTION / 解像度: 1.806 Å PDB-6deo: Crystal structure of Candida albicans acetohydroxyacid synthase in complex with the herbicide iodomuron methyl 手法: X-RAY DIFFRACTION / 解像度: 1.971 Å PDB-6dep: Crystal structure of Candida albicans acetohydroxyacid synthase in complex with the herbicide sulfometuron methyl 手法: X-RAY DIFFRACTION / 解像度: 2.149 Å PDB-6deq: Crystal structure of Candida albicans acetohydroxyacid synthase in complex with the herbicide penoxsulam 手法: X-RAY DIFFRACTION / 解像度: 2.127 Å PDB-6der: Crystal structure of Candida albicans acetohydroxyacid synthase in complex with the herbicide metosulam 手法: X-RAY DIFFRACTION / 解像度: 2.126 Å PDB-6des: Crystal structure of Candida albicans acetohydroxyacid synthase in complex with the herbicide propoxycarbazone 手法: X-RAY DIFFRACTION / 解像度: 2.402 Å
化合物	ChemComp-FAD: FLAVIN-ADENINE DINUCLEOTIDE / FAD / FADYM ChemComp-K: Unknown entry / カリウムカチオン ChemComp-MG: Unknown entry / マグネシウムジカチオン ChemComp-TPP: THIAMINE DIPHOSPHATE / 3-[(4-アミノ-2-メチル-5-ピリミジニル)メチル]-4-メチル-5-[2-(ホスホノオキシホスフィナトオキシ)(以下略) ChemComp-HOH: WATER ChemComp-CIE: 2-[[[[(4-CHLORO-6-METHOXY-2-PYRIMIDINYL)AMINO]CARBONYL]AMINO]SULFONYL]BENZOIC ACID ETHYL ESTER / クロリムロンエチル ChemComp-TP9: (3Z)-4-{[(4-AMINO-2-METHYLPYRIMIDIN-5-YL)METHYL]AMINO}-3-MERCAPTOPENT-3-EN-1-YL TRIHYDROGEN DIPHOSPHATE ChemComp-G8G: (3Z)-4-{[(4-amino-2-methylpyrimidin-5-yl)methyl](formyl)amino}-3-sulfanylpent-3-en-1-yl trihydrogen diphosphate ChemComp-FMT: FORMIC ACID / ギ酸 ChemComp-60G: methyl 2-[(4,6-dimethoxypyrimidin-2-yl)carbamoylsulfamoylmethyl]benzoate / ベンスルフロンメチル ChemComp-G8A: ethyl 2-{[(4-iodo-6-methoxypyrimidin-2-yl)carbamoyl]sulfamoyl}benzoate ChemComp-CO2: CARBON DIOXIDE / 二酸化炭素 ChemComp-H4V: methyl 2-{[(4-iodo-6-methoxypyrimidin-2-yl)carbamoyl]sulfamoyl}benzoate ChemComp-1SM: METHYL 2-[({[(4,6-DIMETHYLPYRIMIDIN-2-YL)AMINO]CARBONYL}AMINO)SULFONYL]BENZOATE / スルホメツロンメチル ChemComp-TZD: 2-{3-[(4-AMINO-2-METHYLPYRIMIDIN-5-YL)METHYL]-4-METHYL-2-OXO-2,3-DIHYDRO-1,3-THIAZOL-5-YL}ETHYL TRIHYDROGEN / チアミンチアゾロン二りん酸 ChemComp-PXD: 2-(2,2-difluoroethoxy)-N-(5,8-dimethoxy[1,2,4]triazolo[1,5-c]pyrimidin-2-yl)-6-(trifluoromethyl)benzenesulfonamide / ペノキススラム ChemComp-G87: Metosulam / メトスラム ChemComp-6R4*: methyl 2-[(4-methyl-5-oxidanylidene-3-propoxy-1,2,4-triazol-1-yl)carbonylsulfamoyl]benzoate / 2-[[(3-プロポキシ-4-メチル-5-オキソ-4,5-ジヒドロ-1H-1,2,4-トリアゾ-ル)-1-イルカルボニ(以下略)
由来	candida albicans (strain sc5314 / atcc mya-2876) (酵母)
キーワード	transferase/transferase inhibitor / AHAS / acetohydroxyacid synthase / acetolactate synthase / herbicide / thiamin diphosphate / FAD / transferase / transferase-transferase inhibitor complex / chlorimuron ethyl / sulfonylurea / bensulfuron methyl / iodomuron ethyl / sulfometuron methyl / penoxsulam / triazolopyrimidine / metosulam / propoxycarbazone / sulfonylamino-carbonyl-triazolinone