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Structure paper

TitleI260Q DNA polymerase beta highlights precatalytic conformational rearrangements critical for fidelity.
Journal, issue, pagesNucleic Acids Res., Vol. 46, Page 10740-10756, Year 2018
Publish dateDec 6, 2017 (structure data deposition date)
AuthorsLiptak, C. / Mahmoud, M.M. / Eckenroth, B.E. / Moreno, M.V. / East, K. / Alnajjar, K.S. / Huang, J. / Towle-Weicksel, J.B. / Doublie, S. / Loria, J.P. / Sweasy, J.B.
External linksNucleic Acids Res. / PubMed:30239932
MethodsX-ray diffraction
Resolution1.75 - 2.2 Å
Structure data

PDB-6bte:
DNA Polymerase Beta I260Q Binary Complex
Method: X-RAY DIFFRACTION / Resolution: 2.2 Å

PDB-6btf:
DNA Polymerase Beta I260Q Ternary Complex
Method: X-RAY DIFFRACTION / Resolution: 1.75 Å

Chemicals

ChemComp-NA:
Unknown entry

ChemComp-CL:
Unknown entry

ChemComp-IOD:
IODIDE ION

ChemComp-HOH:
WATER

ChemComp-MG:
Unknown entry

ChemComp-DUP:
2'-DEOXYURIDINE 5'-ALPHA,BETA-IMIDO-TRIPHOSPHATE

Source
  • homo sapiens (human)
KeywordsTRANSFERASE / LYASE/DNA / Lyase / DNA complex / LYASE-DNA complex

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