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-Structure paper
Title | Allosteric Activation of Striatal-Enriched Protein Tyrosine Phosphatase (STEP, PTPN5) by a Fragment-like Molecule. |
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Journal, issue, pages | J. Med. Chem., Vol. 62, Page 306-316, Year 2019 |
Publish date | Aug 3, 2018 (structure data deposition date) |
![]() | Tautermann, C.S. / Binder, F. / Buttner, F.H. / Eickmeier, C. / Fiegen, D. / Gross, U. / Grundl, M.A. / Heilker, R. / Hobson, S. / Hoerer, S. ...Tautermann, C.S. / Binder, F. / Buttner, F.H. / Eickmeier, C. / Fiegen, D. / Gross, U. / Grundl, M.A. / Heilker, R. / Hobson, S. / Hoerer, S. / Luippold, A. / Mack, V. / Montel, F. / Peters, S. / Bhattacharya, S. / Vaidehi, N. / Schnapp, G. / Thamm, S. / Zeeb, M. |
![]() | ![]() ![]() |
Methods | X-ray diffraction |
Resolution | 1.66 - 1.771 Å |
Structure data | ![]() PDB-6h8r: ![]() PDB-6h8s: |
Chemicals | ![]() ChemComp-SO4: ![]() ChemComp-FWB: ![]() ChemComp-HOH: ![]() ChemComp-FSZ: |
Source |
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![]() | HYDROLASE / PROTEIN PHOSPHATASE / PTN5 / STEP / ALLOSTERIC MODULATOR |