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TitleStructural Basis of Pan-Ebolavirus Neutralization by a Human Antibody against a Conserved, yet Cryptic Epitope.
Journal, issue, pagesMBio, Vol. 9, Year 2018
Publish dateAug 2, 2018 (structure data deposition date)
AuthorsWest, B.R. / Moyer, C.L. / King, L.B. / Fusco, M.L. / Milligan, J.C. / Hui, S. / Saphire, E.O.
External linksMBio / PubMed:30206174
MethodsX-ray diffraction
Resolution4.25 - 4.75 Å
Structure data

PDB-6ea5:
Structure of BDBV GPcl in complex with the pan-ebolavirus mAb ADI-15878
Method: X-RAY DIFFRACTION / Resolution: 4.75 Å

PDB-6ea7:
Structure of EBOV GPcl in complex with the pan-ebolavirus mAb ADI-15878
Method: X-RAY DIFFRACTION / Resolution: 4.25 Å

Chemicals

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

Source
  • bundibugyo ebolavirus
  • homo sapiens (human)
  • ebola virus
KeywordsVIRAL PROTEIN/immune system / mAb / GP / glycoprotein / Ebola / EBOV / antibody / BDBV / bundibugyo / neutralization / immune / bnAb / complex / filovirus / VIRAL PROTEIN / VIRAL PROTEIN-immune system complex

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