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TitleIdentification of the First PPAR alpha / gamma Dual Agonist Able To Bind to Canonical and Alternative Sites of PPAR gamma and To Inhibit Its Cdk5-Mediated Phosphorylation.
Journal, issue, pagesJ. Med. Chem., Vol. 61, Page 8282-8298, Year 2018
Publish dateMar 12, 2013 (structure data deposition date)
AuthorsLaghezza, A. / Piemontese, L. / Cerchia, C. / Montanari, R. / Capelli, D. / Giudici, M. / Crestani, M. / Tortorella, P. / Peiretti, F. / Pochetti, G. ...Laghezza, A. / Piemontese, L. / Cerchia, C. / Montanari, R. / Capelli, D. / Giudici, M. / Crestani, M. / Tortorella, P. / Peiretti, F. / Pochetti, G. / Lavecchia, A. / Loiodice, F.
External linksJ. Med. Chem. / PubMed:30199253
MethodsX-ray diffraction
Resolution2.1 - 2.5 Å
Structure data

PDB-4jl4:
Crystal structure of the complex between PPARgamma LBD and the ligand LJ570 [(2S)-3-(biphenyl-4-yl)-2-(biphenyl-4-yloxy)propanoic acid]
Method: X-RAY DIFFRACTION / Resolution: 2.5 Å

PDB-6f2l:
Crystal structure of the complex between PPARgamma LBD and the ligand LJ570: structure obtained from crystals of the apo-form soaked for 15 days.
Method: X-RAY DIFFRACTION / Resolution: 2.1 Å

Chemicals

ChemComp-AXY:
(2S)-3-(biphenyl-4-yl)-2-(biphenyl-4-yloxy)propanoic acid

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTranscription/Agonist / BUNDLE OF ALPHA-HELICES / SMALL FOUR-STRNDED BETA-SHEET / transcription factor / RXR / Transcription-Agonist complex / TRANSCRIPTION / nuclear receptor / complex with an agonist

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