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Structure paper

TitleStructural basis for polymerase eta-promoted resistance to the anticancer nucleoside analog cytarabine.
Journal, issue, pagesSci Rep, Vol. 8, Page 12702-12702, Year 2018
Publish dateApr 10, 2018 (structure data deposition date)
AuthorsRechkoblit, O. / Choudhury, J.R. / Buku, A. / Prakash, L. / Prakash, S. / Aggarwal, A.K.
External linksSci Rep / PubMed:30140014
MethodsX-ray diffraction
Resolution1.75 - 1.832 Å
Structure data

PDB-6d0m:
Polymerase Eta post-insertion binary complex with cytarabine (AraC)
Method: X-RAY DIFFRACTION / Resolution: 1.832 Å

PDB-6d0z:
Polymerase Eta cytarabine (AraC) extension ternary complex
Method: X-RAY DIFFRACTION / Resolution: 1.75 Å

Chemicals

ChemComp-GOL:
GLYCEROL

ChemComp-HOH:
WATER

ChemComp-MG:
Unknown entry

ChemComp-DZ4:
2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]adenosine

Source
  • homo sapiens (human)
  • synthetic construct (others)
KeywordsTRANSFERASE/DNA / Cytarabine / AraC / DNA damage / Translesion / DNA synthesis / DNA Replication / TRANSFERASE / TRANSFERASE-DNA complex

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