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-Structure paper
Title | Discovery of Asciminib (ABL001), an Allosteric Inhibitor of the Tyrosine Kinase Activity of BCR-ABL1. |
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Journal, issue, pages | J. Med. Chem., Vol. 61, Page 8120-8135, Year 2018 |
Publish date | Aug 17, 2018 (structure data deposition date) |
![]() | Schoepfer, J. / Jahnke, W. / Berellini, G. / Buonamici, S. / Cotesta, S. / Cowan-Jacob, S.W. / Dodd, S. / Drueckes, P. / Fabbro, D. / Gabriel, T. ...Schoepfer, J. / Jahnke, W. / Berellini, G. / Buonamici, S. / Cotesta, S. / Cowan-Jacob, S.W. / Dodd, S. / Drueckes, P. / Fabbro, D. / Gabriel, T. / Groell, J.M. / Grotzfeld, R.M. / Hassan, A.Q. / Henry, C. / Iyer, V. / Jones, D. / Lombardo, F. / Loo, A. / Manley, P.W. / Pelle, X. / Rummel, G. / Salem, B. / Warmuth, M. / Wylie, A.A. / Zoller, T. / Marzinzik, A.L. / Furet, P. |
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Methods | X-ray diffraction |
Resolution | 2.03 - 2.3 Å |
Structure data | ![]() PDB-6hd4: ![]() PDB-6hd6: |
Chemicals | ![]() ChemComp-GOL: ![]() ChemComp-CL: ![]() ChemComp-FYW: ![]() ChemComp-STI: ![]() ChemComp-HOH: ![]() ChemComp-FYH: |
Source |
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![]() | TRANSFERASE / PHOSPHOTRANSFERASE / Inhibitor complex |