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-Structure paper
Title | Generation and characterization of a high affinity anti-human FcRn antibody, rozanolixizumab, and the effects of different molecular formats on the reduction of plasma IgG concentration. |
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Journal, issue, pages | MAbs, Vol. 10, Page 1111-1130, Year 2018 |
Publish date | Jan 10, 2018 (structure data deposition date) |
Authors | Smith, B. / Kiessling, A. / Lledo-Garcia, R. / Dixon, K.L. / Christodoulou, L. / Catley, M.C. / Atherfold, P. / D'Hooghe, L.E. / Finney, H. / Greenslade, K. ...Smith, B. / Kiessling, A. / Lledo-Garcia, R. / Dixon, K.L. / Christodoulou, L. / Catley, M.C. / Atherfold, P. / D'Hooghe, L.E. / Finney, H. / Greenslade, K. / Hailu, H. / Kevorkian, L. / Lightwood, D. / Meier, C. / Munro, R. / Qureshi, O. / Sarkar, K. / Shaw, S.P. / Tewari, R. / Turner, A. / Tyson, K. / West, S. / Shaw, S. / Brennan, F.R. |
External links | MAbs / PubMed:30130439 |
Methods | X-ray diffraction |
Resolution | 2.9 Å |
Structure data | PDB-6fgb: |
Chemicals | ChemComp-CL: ChemComp-NA: ChemComp-HOH: |
Source |
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Keywords | IMMUNE SYSTEM / FcRn / rozanolixizumab / ECD / Fab |