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Title | Potent and Orally Bioavailable Inverse Agonists of ROR gamma t Resulting from Structure-Based Design. |
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Journal, issue, pages | J. Med. Chem., Vol. 61, Page 7796-7813, Year 2018 |
Publish date | Mar 23, 2017 (structure data deposition date) |
Authors | Narjes, F. / Xue, Y. / von Berg, S. / Malmberg, J. / Llinas, A. / Olsson, R.I. / Jirholt, J. / Grindebacke, H. / Leffler, A. / Hossain, N. ...Narjes, F. / Xue, Y. / von Berg, S. / Malmberg, J. / Llinas, A. / Olsson, R.I. / Jirholt, J. / Grindebacke, H. / Leffler, A. / Hossain, N. / Lepisto, M. / Thunberg, L. / Leek, H. / Aagaard, A. / McPheat, J. / Hansson, E.L. / Back, E. / Tangefjord, S. / Chen, R. / Xiong, Y. / Hongbin, G. / Hansson, T.G. |
External links | J. Med. Chem. / PubMed:30095900 |
Methods | X-ray diffraction |
Resolution | 1.82 - 2.45 Å |
Structure data | PDB-5ni5: PDB-5ni7: PDB-5ni8: PDB-5nib: PDB-6esn: PDB-6fgq: |
Chemicals | ChemComp-8YB: ChemComp-NA: ChemComp-HOH: ChemComp-8Y8: ChemComp-DMS: ChemComp-8Y2: ChemComp-8Y5: ChemComp-BWE: ChemComp-D9N: |
Source |
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Keywords | TRANSCRIPTION / RAR-related Orphan Receptor-g (RORg) / RORG LIGAND / STRUCTURE-BASED DESIGN |