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Title | Structural Optimization of a Pyridinylimidazole Scaffold: Shifting the Selectivity from p38 alpha Mitogen-Activated Protein Kinase to c-Jun N-Terminal Kinase 3. |
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Journal, issue, pages | ACS Omega, Vol. 3, Page 7809-7831, Year 2018 |
Publish date | Sep 26, 2017 (structure data deposition date) |
![]() | Ansideri, F. / Macedo, J.T. / Eitel, M. / El-Gokha, A. / Zinad, D.S. / Scarpellini, C. / Kudolo, M. / Schollmeyer, D. / Boeckler, F.M. / Blaum, B.S. ...Ansideri, F. / Macedo, J.T. / Eitel, M. / El-Gokha, A. / Zinad, D.S. / Scarpellini, C. / Kudolo, M. / Schollmeyer, D. / Boeckler, F.M. / Blaum, B.S. / Laufer, S.A. / Koch, P. |
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Methods | X-ray diffraction |
Resolution | 1.76 - 2.1 Å |
Structure data | ![]() PDB-6ekd: ![]() PDB-6emh: ![]() PDB-6eq9: |
Chemicals | ![]() ChemComp-BME: ![]() ChemComp-EDO: ![]() ChemComp-B9K: ![]() ChemComp-HOH: ![]() ChemComp-CL: ![]() ChemComp-BGE: ![]() ChemComp-C15: ![]() ChemComp-PEG: ![]() ChemComp-GOL: ![]() ChemComp-MG: ![]() ChemComp-NA: ![]() ChemComp-ACP: |
Source |
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![]() | TRANSFERASE / Protein Kinase Activity Map Kinase Activity ATP Binding Protein Phosphorylation / Protein Kinase Activiy Map Kinase Activity ATP Binding Protein Phosphorylation |