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TitleJQ1 affects BRD2-dependent and independent transcription regulation without disrupting H4-hyperacetylated chromatin states.
Journal, issue, pagesEpigenetics, Vol. 13, Page 410-431, Year 2018
Publish dateSep 15, 2017 (structure data deposition date)
AuthorsHandoko, L. / Kaczkowski, B. / Hon, C.C. / Lizio, M. / Wakamori, M. / Matsuda, T. / Ito, T. / Jeyamohan, P. / Sato, Y. / Sakamoto, K. ...Handoko, L. / Kaczkowski, B. / Hon, C.C. / Lizio, M. / Wakamori, M. / Matsuda, T. / Ito, T. / Jeyamohan, P. / Sato, Y. / Sakamoto, K. / Yokoyama, S. / Kimura, H. / Minoda, A. / Umehara, T.
External linksEpigenetics / PubMed:30080437
MethodsX-ray diffraction
Resolution1.7 - 1.799 Å
Structure data

PDB-5ye3:
Crystal structure of the complex of di-acetylated histone H4 and 2A7D9 Fab fragment
Method: X-RAY DIFFRACTION / Resolution: 1.7 Å

PDB-5ye4:
Crystal structure of the complex of di-acetylated histone H4 and 1A9D7 Fab fragment
Method: X-RAY DIFFRACTION / Resolution: 1.799 Å

Chemicals

ChemComp-HOH:
WATER

ChemComp-ZN:
Unknown entry

Source
  • mus musculus (house mouse)
  • homo sapiens (human)
KeywordsNUCLEAR PROTEIN / Antibody / Histone / Complex

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